Anti-4-1BB/CD137 Rabbit (Clone RM471)

4-1BB, also known as CD137, is a type I transmembrane glycoprotein and member of the TNF receptor superfamily with roles in T cell-mediated immunity. It is composed of an N-terminal extracellular domain comprising a signaling sequence and four cysteine-rich pseudo repeats (CRDs), a helical transmembrane domain, and a cytoplasmic signaling domain. 4-1BB is transiently expressed on antigen-primed activated T cells, activated natural killer (NK) cells, and mature dendritic cells. Binding of homotrimeric 4-1BB ligand on antigen-primed T cells induces NF-kappaB and MAPK signaling through TNF receptor-associated factors (TRAFs) and, when the T cell is co-stimulated by other factors, induces PI3K signaling. This bidirectional signaling event promotes clonal expansion, differentiation, and survival of T cells, as well as polarizes T helper cells. Knockout of Tnfrsf9, the gene encoding 4-1BB, reduces pancreatic islet accumulation of beta-cell-autoreactive CD8+ T cells in a mouse model of type 1 diabetes mellitus. Administration of an anti-4-1BB antibody prolongs survival and reverses renal damage, production of autoantibodies, and immune complex deposition in lupus-prone NZB X NZW F1 mice. Cayman's 4-1BB/CD137 Rabbit Monoclonal Antibody (Clone RM471) can be used for flow cytometry (FC), immunohistochemistry (IHC), and Western blot (WB) applications.. Cross reactivity: (+) 4-1BB: .. Protein function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. [The UniProt Consortium]