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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES1548.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES1548.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile... more
Product information "Anti-3beta-HSD7"
This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008], Protein function: The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. [The UniProt Consortium] Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.. Cellular localization: Endoplasmic reticulum membrane, Multi-pass membrane protein.
Keywords: | EC=1.1.1.-, Anti-3-beta-HSD VII, Anti-C(27) 3-beta-HSD, Anti-3 beta-hydroxysteroid dehydrogenase type 7, Anti-3 beta-hydroxysteroid dehydrogenase type VII, Anti-3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase, Anti-Cholest-5-ene-3-beta, 3beta-HSD7 rabb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES1548 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | The antiserum was produced against synthesized peptide derived from human HSD3B7. AA range:121-170 |
MW: | 41 kD |
Format: | Antiserum |
Database Information
KEGG ID : | K12408 | Matching products |
UniProt ID : | Q9H2F3 | Matching products |
Gene ID | GeneID 80270 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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