Products from SYNkinase
SYNkinase, headquartered in Australia, is a primary producer of research-use-only biomedical reagents, which it markets to life-science and drug-discovery researchers affiliated with universities, research institutes and industry. SYNkinase was established in 2008 by Professor Andrew Wilks and Dr. Xian Bu. The founders of the company have been involved in pharmaceutical drug discovery for three decades and have extensive scientific, company and board experience.
More information at: www.adipogen.com/synkinase
No results were found for the filter!
RG-7422
Item number: SYN-1150-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GDC-0980 (RG7422) is a selective, dual PI3 Kinase and mTOR Kinase inhibitor with IC(50) values of 5, 27, 7, and 14nM for PI3Kalpha-delta respectively. It inhibits mTOR with a Ki of 17nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Keywords: | GDC-0980 |
| Application: | PI3K / mTOR inhibitor |
| CAS | 1032754-93-0 |
| MW: | 498,6 D |
From 132.00€
*
SGX-523
Item number: SYN-1155-M001
Soluble in DMSO. Slightly soluble ( 36%, suggesting IC(50) values > 1µM, including the closely-associated RON kinase. Target: c-Met , Kinase Group: RTK , Substrate: Tyrosine
| Keywords: | SGX523 |
| Application: | c-Met inhibitor |
| CAS | 1072116-01-8 |
| MW: | 359,4 D |
From 132.00€
*
Takeda-6d
Item number: SYN-1168-M001
Soluble in DMSO. Takeda-6d has potent inhibitory activity in both B-RAF with an IC(50) of 7.0nM and VEGFR2 with an IC(50) of 2.2nM. Target: B-RAF - VEGFR2 , Kinase Group: TKL , Substrate: Serine-Threonine
| Keywords: | Takeda 6d |
| Application: | B-RAF / VEGFR2 inhibitor |
| CAS | 1125632-93-0 |
| MW: | 548 D |
From 256.00€
*
BGT-226 maleate
Item number: SYN-1178-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. BGT226 is a novel, orally bioavailable small-molecule inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin with an IC(50) of 1nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Keywords: | NVP-BEZ226, BEZ-226 |
| Application: | PI3K / mTOR inhibitor |
| CAS | 1245537-68-1 |
| MW: | 650,6 D |
From 119.00€
*
GNF-5837
Item number: SYN-1183-M001
Soluble in DMSO. Inhibitor of pan-Trk activity (IC(50) = 8 and 12nM for TrkA and TrkB). Shown to target Trk (tropomyosin receptor kinase) ATP binding cleft and an immediately adjacent hydrophobic pocket. Preferentially arrests the proliferation of Ba/F3 cells fused with Tel-TrkA, Tel-TrkB and Tel-TrkC (IC(50) = 11,...
| Keywords: | GNF5837 |
| Application: | TrkA / TrkB inhibitor |
| CAS | 1033769-28-6 |
| MW: | 535,5 D |
From 106.00€
*
CH-4987655
Item number: SYN-1188-M001
Soluble in DMSO. CH4987655 (RO4987655) is an orally active and highly selective small-molecule MEK inhibitor with an in vitro IC(50) of 5.2nM. Target: MEK , Kinase Group: PTK , Substrate: Tyrosine
| Keywords: | RO4987655 |
| Application: | MEK inhibitor |
| CAS | 874101-00-5 |
| MW: | 565,3 D |
From 250.00€
*
SGI-1776
Item number: SYN-1193-M001
Soluble in DMSO or ethanol. SGI-1776 is a novel ATP competitive inhibitor of Pim1 with an IC(50) of 7nM, 50- and 10-fold selectivity versus Pim2 and Pim3. Target: Pim1 - Pim2 - Pim3 , Kinase Group: CAMK , Substrate: Serine-Threonine
| Keywords: | SGI1776 |
| Application: | Pim1 / Pim2 / Pim3 inhibitor |
| CAS | 1025065-69-3 |
| MW: | 405,4 D |
From 106.00€
*
PF-04979064
Item number: SYN-1194-M001
Soluble in DMSO. PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM. Target: PI3K - mTOR , Kinase Group: Lipid Kinase , Substrate: Lipid
| Keywords: | PF04979064 |
| Application: | PI3K / mTOR inhibitor |
| CAS | 1220699-06-8 |
| MW: | 446,5 D |
From 256.00€
*
GDC-046
Item number: SYN-1198-M001
Soluble in DMSO. GDC046 is a potent lead analog with good kinase selectivity, physicochemical properties, and pharmacokinetic profile Target: TYK2 , Kinase Group: PTK , Substrate: Tyrosine
| Keywords: | GDC046 |
| Application: | TYK2 inhibitor |
| CAS | 1258292-64-6 |
| MW: | 350,2 D |
From 119.00€
*
LDK378
Item number: SYN-1199-M001
Soluble in DMSO (heat) or ethanol. LDK378 is potent inhibitor against ALK with IC(50) of 0.2nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively. Target: ALK , Kinase Group: RTK , Substrate: Tyrosine
| Keywords: | LDK-378 |
| Application: | ALK inhibitor |
| CAS | 1032900-25-6 |
| MW: | 558,1 D |
From 79.00€
*
GDC-0032
Item number: SYN-1202-M001
Slightly soluble ( 10 fold selective over PI3Kbeta Target: PI3K , Kinase Group: Lipid Kinases , Substrate: Lipid
| Keywords: | GDC0032 |
| Application: | PI3K alpha / delta / gamma inhibitor |
| CAS | 1282512-48-4 |
| MW: | 460,5 D |
From 106.00€
*
URMC-099
Item number: SYN-1211-M001
Solid. Soluble in DMSO or water. Inhibition of mixed lineage kinase 3 (MLK-3) is a potential strategy for the treatment of Parkinson's disease and HIV-1 associated neuro-cognitive disorders (HAND), requiring an inhibitor that can achieve significant brain concentration levels. URMC-099 is an orally bioavailable...
| Keywords: | 3-(1H-Indol-5-yl)-5-(4-(4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3- b]pyridine |
| Application: | MLK-3 inhibitor |
| CAS | 1229582-33-5 |
| MW: | 421,5 D |
From 132.00€
*