GrpE, co-chaperone of E.coli, participates actively in the response to hyperosomotic and heat shock by preventing the aggregation of stress-denatured proteins in association with DnaK. This protein is the nucleotide exchange factor for DnaK and may function as a thermosensor. Several rounds of ATP-dependent...

GrpE is an acidic 24kD protein which is encoded by a monocistronic Escherichia coli gene (located at 56 min.) which is under the control of both s32 and s70 transcription factors (1). The GrpE protein is a so-called co-chaperone because it is known to assist the DnaK (Hsp70) protein to effectively carry out...