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Item number: Cay37400-1

AP1189 is a biased agonist of melanocortin receptor 1 (MC1R) and MC3R. It induces ERK1 and ERK2 phosphorylation but not canonical cAMP production in HEK293 cells expressing human MC1R or MC3R when used at concentrations ranging from 10 pM to 1 mM. AP1189 (0.1-10 nM) reduces zymosan-induced IL-1beta, IL-6, and...

Keywords:	2-[3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]-2-propen-1-ylidene]-hydrazinecarboximidamide, acetate
Application:	Biased MC1R / MC3R agonist
CAS	959850-74-9
MW:	358.4 D

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