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YMU1
Item number: Cay21981-5
YMU1 is an inhibitor of thymidylate kinase (TMPK, IC50 = 610 nM). It is selective for thymidylate kinase over thymidine kinase 1. YMU1 (2 and 10 µM) reduces deoxythymidine triphosphate (dTTP) levels by 30-40% in p58-/- HCT116 cells without affecting dATP, dGTP, or dCTP levels. It also sensitizes a variety of cancer...
| Keywords: | 4-[2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl]-1-piperazinecarboxylic acid, ethyl ester |
| Application: | DTYMK inhibitor |
| CAS | 902589-96-2 |
| MW: | 378.5 D |
From 132.00€
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Thymidylate Kinase Inhibitor, YMU1
Item number: TGM-T8864-100mg
Description: YMU1 is a human thymidylate kinase (hTMPK) inhibitor. YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Target: Others. Smiles: O=C1C=2C(SN1CC(=O)N3CCN(C(OCC)=O)CC3)=NC(C)=CC2C. References: Dong B , Jaeger A M , Hughes...
| Application: | Thymidylate Kinase inhibitor |
| CAS | 902589-96-2 |
| MW: | 378.45 D |
From 41.00€
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