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Item number: Cay21981-5

YMU1 is an inhibitor of thymidylate kinase (TMPK, IC50 = 610 nM). It is selective for thymidylate kinase over thymidine kinase 1. YMU1 (2 and 10 µM) reduces deoxythymidine triphosphate (dTTP) levels by 30-40% in p58-/- HCT116 cells without affecting dATP, dGTP, or dCTP levels. It also sensitizes a variety of cancer...

Keywords:	4-[2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl]-1-piperazinecarboxylic acid, ethyl ester
Application:	DTYMK inhibitor
CAS	902589-96-2
MW:	378.5 D

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