2 products were found matching "874119-56-9"!
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GSK25
Item number: Cay39163-1
GSK25 is an inhibitor of Rho-associated kinase 1 (ROCK1, IC50 = 7 nM for the human kinase). It is selective for ROCK1 over p90 ribosomal S6 kinase 1 (RSK1) and p70 ribosomal S6 kinase (p70S6K, IC50s = 398 and 1,000 nM, respectively) and is greater than 100-fold selective over a panel of 31 additional kinases. GSK25...
| Keywords: | 4-(4-chloro-2-fluorophenyl)-2-(2-chloro-4-pyridinyl)-N-(6-fluoro-1H-indazol-5-yl)-1,4-dihydro-6-methyl-5-pyrimidinecarboxa... |
| Application: | ROCK1 inhibitor |
| CAS | 874119-56-9 |
| MW: | 513.3 D |
From 82.00€
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GSK-25
Item number: SYN-1124-M001
Soluble in DMSO. GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC(50) of 398nM, p70S6K IC(50) of 1000nM), and a dramatically improved P450 profile (>2.2µM at all isozymes tested). Target: RSK1 - p70S6K , Kinase Group: AGC , Substrate: Serine-Threonine
| Keywords: | GSK-25 |
| Application: | RSK1 / p70S6K inhibitor |
| CAS | 874119-56-9 |
| MW: | 513,3 D |
From 250.00€
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