RO4987655 is a MEK inhibitor (IC50 = 5 nM). It is selective for MEK over 400 kinases at 10 µM. It inhibits proliferation of COLO 205, HT-29, QG56, MIA PaCa-2, and C32 cells with IC50 values of 0.86, 1.7, 9.5, 3.3, and 8.4 nM, respectively. RO4987655 reduces tumor growth in a variety of mouse xenograft models and...

Soluble in DMSO. CH4987655 (RO4987655) is an orally active and highly selective small-molecule MEK inhibitor with an in vitro IC(50) of 5.2nM. Target: MEK , Kinase Group: PTK , Substrate: Tyrosine