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GSK429286A
Item number: Cay15262-10
GSK429286A is a cell-permeable inhibitor of Rho-associated kinase (IC50 = 14 nM). It less potently inhibits p90 and p70 ribosomal S6 kinases (IC50s = 780 and 1,940 nM, respectively) and is ineffective against leucine-rich repeat protein kinase-2. GSK429286A reverses adrenalin-induced contraction of rat aortic rings...
| Keywords: | N-(6-fluoro-1H-indazol-5-yl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-3-pyridinecarboxamide |
| Application: | Cell-permeable Rho-associated kinase inhibitor |
| CAS | 864082-47-3 |
| MW: | 432.4 D |
From 46.00€
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GSK-429286A
Item number: LKT-G7443.1
GSK-429286A is an inhibitor of ROCK1/2 that also exhibits some inhibition of RSK and p70S6K. GSK-429286A displays antihypertensive activity, decreasing mean arterial pressure in spontaneously hypertensive rats.
| Keywords: | GSK429286A |
| Application: | Cell-permeable Rho-associated kinase inhibitor |
| CAS | 864082-47-3 |
| MW: | 432.37 D |
From 137.00€
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GSK429286A
Item number: SYN-1071-M001
Soluble in DMSO. GSK429286A is a potent and selective inhibitor of Rho-associated kinase (ROCK1), with an IC(50) of 14nM. It is orally available and has been shown to dramatically reduce mean arterial pressure in spontaneously hypertensive rats. Target: ROCK , Kinase Group: AGC , Substrate: Serine-Threonine
| Keywords: | GSK-429286A, RHO-15 |
| Application: | ROCK inhibitor |
| CAS | 864082-47-3 |
| MW: | 432,4 D |
From 119.00€
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