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Item number: Cay22440-5

PKF118-310 is an inhibitor of the protein-protein interaction between T cell factor 4 (Tcf4) and beta-catenin that is produced by Actinomycete strains. It disrupts binding of beta-catenin to a GST-Tcf4 fusion protein in HCT116 cell lysates (IC50 = 0.8 µM). PKF118-310 blocks appearance of the Tcf4 and beta-catenin...

Keywords:	NSC 67078, Toxoflavin, 1,6-dimethyl-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione
Application:	Survivin expression inhibitor, Tcf4/beta-catenin signaling antagonist
CAS	84-82-2
MW:	193.2 D

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