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AK-1
Item number: Cay21276-10
AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50 = 12.5 µM). It induces the formation of alpha-synuclein aggregates in H4 neuroglioma cells expressing alpha-synuclein and synphilin-1. AK-1 (5 µM) decreases total cholesterol levels in Neuro2a and primary rat striatal neurons, as well as in hippocampal slice cultures. It...
| Keywords: | 3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)-benzamide |
| Application: | SIRT2 inhibitor |
| CAS | 330461-64-8 |
| MW: | 403.5 D |
From 77.00€
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AK-1
Item number: LKT-A4000.10
AK-1 is an inhibitor of sirtuin 2 (SIRT2), sirtuins are considered class III histone deacetylases (HDACs). AK-1 exhibits neuroprotective activity, preventing some hippocampal neurodegeneration in animal models of Alzheimer's disease.
| Keywords: | SIRT2 inhibitor II |
| Application: | SIRT2 inhibitor |
| CAS | 330461-64-8 |
| MW: | 403.45 D |
From 108.00€
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