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Item number: Cay33975-10

Roflumilast N-oxide is an inhibitor of phosphodiesterase 4 (PDE4, IC50 = 2 nM) and an active metabolite of the PDE4 inhibitor roflumilast (Cay-15141). It is selective for PDE4 over PDE1-3 and PDE5 (IC50s = >10,000 nM for all). It reduces TNF-alpha-induced ICAM-1 and eotaxin levels when used in combination with...

Keywords:	3-(cyclopropylmethoxy)-N-(3,5-dichloro-1-oxido-4-pyridinyl)-4-(difluoromethoxy)-benzamide
Application:	PDE4 inhibitor
CAS	292135-78-5
MW:	419.2 D

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