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Item number: Cay35777-1

BMS-299897 is an inhibitor of gamma-secretase. It selectively cleaves the carboxy terminal fragment (CTF) of amyloid precursor protein (APP) over the Notch-1 CTF in HEK293 cells (IC50s = 7.1 and 105.9 nM, respectively). BMS-299897 (0.1-1 nmol/animal) reduces increases in amyloid-beta (1-42) (Abeta42) levels induced...

Keywords:	2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-benzenebutanoic acid
Application:	Gamma-secretase inhibitor
CAS	290315-45-6
MW:	511.9 D

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