2 products were found matching "1446144-04-2"!

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Item number: Cay15479-1

(+)-JQ1 (Cay-11187) binds to the acetyl-lysine recognition pocket of bromodomains 1 and 2 on BRD4 with Kd values of ~50 and 90 nM, respectively. This displaces BRD4 from nuclear chromatin in cells, inducing differentiation and growth arrest in midline carcinoma cells. CPI-203 is a primary amide analog of (+)-JQ1...

Keywords:	(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Application:	BRD4 binding inhibitor
CAS	1446144-04-2
MW:	399.9 D

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CPI-203

Item number: BPS-82065

CPI-203 is a primary amide analog of (+)-JQ1, which has shown superior bioavailability with oral or i.p. administration. CPI-203 downregulates Myc expression, causes G1 cell cycle arrest and attenuates cell proliferation in human pancreatic neuroendocrine tumors. CPI-203 also arrests the growth of T cell acute...

Keywords:	CPI203, CPI 203,
Application:	BRD4 binding inhibitor
CAS	1446144-04-2
MW:	399,9 D

862.00€ *

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