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Item number: Cay15387-1

Galiellalactone is a fungal metabolite isolated from the ascomycetes G. rufa strain A75-86 and A111-95 that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells with an IC50 value of 0.25-0.5 µM. The selectivity of this compound is achieved by its ability to block the binding of activated STAT3 dimers...

Keywords:	(7bS)-5,5aR,6,7,7aR,7b-hexahydro-7b-hydroxy-4S-methyl-indeno[1,7-bc]furan-2(4H)-one
Application:	JAK/STAT signal transduction inhibitor
CAS	133613-71-5
MW:	194.2 D

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