- Search results for 1236699-92-5
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3 products were found matching "1236699-92-5"!
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Item number: Cay11226-1
The mitogen-activated protein kinases, MEK1 and 2, are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the Ras-Raf-MEK-ERK pathway and are often upregulated in a variety of cancer cell types. AS-703026 is an orally bioavailable small molecule that selectively binds to and...
Keywords: | MSC1936369B, Pimasertib, N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]-4-pyridinecarboxamide |
Application: | MEK1/2 inhibitor |
CAS | 1236699-92-5 |
MW: | 431.2 D |
From 32.00€
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Item number: SYN-1190-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. AS703026 is a novel, selective, non-competitive, orally bioavailable MEK1/2 inhibitor with experimental IC(50) values of 5-11nM. In use on multiple myeloma cells (MM), AS703026 inhibited growth and survival of MM cells and cytokine-induced osteoclast...
Keywords: | AS703026 |
Application: | JAK2 inhibitor |
CAS | 1236699-92-5 |
MW: | 431,2 D |
From 79.00€
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Item number: LKT-A7203.1
AS-703026 is an inhibitor of MEK1/2 that exhibits anticancer chemotherapeutic activity. In vitro, AS-703026 inhibits proliferation of melanoma cells. In both in vitro and in vivo models of colorectal cancer containing WT Ras or mutant KRAS, AS-703026 inhibits growth of cells and also of tumors. Additionally,...
Keywords: | Pimasertib, MSC1936369B |
Application: | MEK1/2 inhibitor |
CAS | 1236699-92-5 |
MW: | 431.2 D |
From 109.00€
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