- Search results for 1229236-86-5
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2 products were found matching "1229236-86-5"!
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Item number: Cay16705-1
LY2784544 is a potent, ATP-competitive inhibitor of janus kinase 2 (JAK2) that less effectively inhibits JAK3 (IC50s = 3 and 48 nM, respectively). It also inhibits JAK2 containing the V617F mutation (IC50 = 20 nM), blocking STAT5 phosphorylation and proliferation of Ba/F3 pro-B-cells expressing this constitutively...
Keywords: | 3-[(4-chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)-imidazo[1,2-b]pyridazin-... |
Application: | JAK2 inhibitor |
CAS | 1229236-86-5 |
MW: | 470 D |
From 84.00€
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Item number: SYN-1196-M001
Soluble in DMSO or ethanol. LY2784544 is a potent JAK2 inhibitor with IC(50) of 3nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2. Target: JAK2 , Kinase Group: PTK , Substrate: Tyrosine
Keywords: | LY-2784544 |
Application: | JAK2 inhibitor |
CAS | 1229236-86-5 |
MW: | 469,9 D |
From 119.00€
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