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Item number: Cay16875-1

AZ 505 is an inhibitor of the lysine N-methyltransferase SMYD2 (IC50 = 0.12 µM). It is selective for SMYD2 over SMYD3, DOT1L, EZH2, GLP, G9A, and SET7/9 (IC50s = >83.3 µM). AZ 505 (10 mg/kg) delays cyst growth in early- and late-stage Pdk1 conditional knockout mouse models of polycystic kidney disease.Formal Name:...

Keywords:	N-cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[2-(3,4-dihydro-5-hydroxy-3-oxo-2H-1,4-benzoxazin-8-yl)ethyl]ami...
Application:	SMYD2 inhibitor
CAS	1035227-43-0
MW:	577.6 D

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