Inflammasomes are multi-protein complexes whose activity has been implicated in physiological and pathological inflammation. The hallmarks of inflammasome activation are the maturation of the cytokines IL-1β and IL-18, and the processing of gasdermin D to mediate cytokine release and pyroptosis from cells of the innate immune system.
Interleukin-17 (IL-17) is a family of 6 closely related cytokines, designated IL-17A-F, that play a central role in mediating inflammation, autoimmunity, and host defense.