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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay11234-100 | 100 µg | - |
6 - 10 business days* |
642.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Vimentin is a cytoskeleton intermediate filament protein present in cells of mesenchymal origin,... more
Product information "Vimentin (human, recombinant)"
Vimentin is a cytoskeleton intermediate filament protein present in cells of mesenchymal origin, including leukocytes, endothelial cells, and smooth muscle cells. Each vimentin monomer contains a central alpha-helix that facilitates formation of the coil-coil dimer required for vimentin filament assembly. Vimentin is attached to nuclei, endoplasmic reticulum, and mitochondria, and has a role in positioning organelles in the cytosol. It regulates glial morphology, facilitates motility and directional migration of fibroblasts, and is critical to mechanotransduction of shear stress and maintenance of vascular endothelial integrity. Vimentin controls transport of LDL-derived cholesterol from lysosomes to esterification sites. It is an aggresome component, forming a cage-like structure around aggregated, undegraded proteins at the microtubule organizing center. Vimentin is subject to citrullination under high calcium concentrations, which can occur during macrophage apoptosis, and citrullinated vimentin has been shown to have a role in the production of anti-citrullinated protein antibodies (ACPAs). ACPAs against citrullinated proteins, such as vimentin, are considered to be highly specific markers for rheumatoid arthritis and other autoimmune diseases.Purity: >90% estimated by SDS-PAGE. Protein Identity Confirmed by Mass Spec: Yes. Source: Recombinant N-terminal histidine-tagged vimentin purified from E. coli. Amino Acids: 2-466. MW: 55.2 kDa. Formulation: (Request formulation change), 10 mM Tris, pH 8.0. UniProt Accession #: P08670.
Keywords: | VIM, Vimentin, Vimentin |
Supplier: | Cayman Chemical |
Supplier-Nr: | 11234 |
Properties
Conjugate: | No |
Species reactivity: | human |
MW: | 55.2 kD |
Purity: | >90% estimated by SDS-PAGE |
Format: | Solution |
Database Information
KEGG ID : | K07606 | Matching products |
UniProt ID : | P08670 | Matching products |
Gene ID | GeneID 7431 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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