Ubiquitin aldehyde (human) (rec.)

Ubiquitin aldehyde (human) (rec.)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
SBB-PS0031-C050 50 µg - -

3 - 9 business days*

211.00€
 
Ubiquitin is a small (8.5kDa) regulatory protein that has been found in almost all tissues of... more
Product information "Ubiquitin aldehyde (human) (rec.)"
Ubiquitin is a small (8.5kDa) regulatory protein that has been found in almost all tissues of eukaryotic organisms. The addition of ubiquitin to a substrate protein is called ubiquitination or ubiquitylation. Ubiquitination can affect proteins in many ways: it can signal for their degradation via the proteasome, alter their cellular location, affect their activity and promote or prevent protein interactions. Removal of ubiquitin from a substrate protein occurs via deconjugating enzymes, of which there are nearly 100 known enzymes with various linkage specificities. This product consists of a full-length human, mature ubiquitin polypeptide (amino acids 1-76), expressed in E.coli with a C-terminal warhead (Aldehyde). Ubiquitin aldehyde is a potent, irreversible and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic aldehyde group. Ubiquitin aldehyde can be used for activity profiling experiments and determining DUB inhibitor specificity. It targets three of the four major DUB families: UCH (Ubiquitin C-terminal hydrolases), USP (Ubiquitin specific proteases), OTU (Ovarian tumor proteases) and MJD (Machado-Josephin domain proteases) while JAMM metalloproteases are not inhibited.
Supplier: South Bay Bio
Supplier-Nr: PS0031

Properties

Application: Assays
Conjugate: No
Host: E.coli
Species reactivity: human
MW: 9 kD
Purity: >97%
Format: Liquid

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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