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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
516822.10 | 10 µg | - | - |
3 - 19 business days* |
341.00€
|
||
516822.50 | 50 µg | - | - |
3 - 19 business days* |
568.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as HVEM, is a protein... more
Product information "Tumor Necrosis Factor Receptor Superfamily Member 14, Recombinant, Mouse, aa39-207, Fc-Tag (Tnfrsf14"
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as HVEM, is a protein that in humans is encoded by the TNFRSF14 gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. It is mapped to 1p36.32. HVEM plays an important role in HSV pathogenesis because it enhanced the entry of several wildtype HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T cells. HVEM and BTLA which are form a bidirectional signaling pathway can regulate cell survival and inhibitory responses between interacting cells. HVEM as an important orchestrator of mucosal immunity integrates signals from innate lymphocytes to induce optimal epithelial Stat3 activation, which indicated that targeting HVEM with agonists could improve host defense. Source: Recombinant partial protein corresponding to aa39-207 of mouse Tumor Necrosis Factor Receptor Superfamily Member 14, fused to Fc-Tag at C-terminal, expressed in mammalian cell. Molecular Weight: ~45.6kD, Biological Activity: The ED50 as determined by its ability to bind human BTLA in functional ELISA is typically 1.17ug/ml. Endotoxin: <1EU/ug (LAL). AA Sequence: QPSCRQEEFLVGDECCPMCNPGYHVKQVCSEHTGTVCAPCPPQTYTAHANGLSKCLPCGVCDPDMGLLTWQECSSWKDTVCRCIPGYFCENQDGSHCSTCLQHTTCPPGQRVEKRGTHDQDTVCADCLTGTFSLGGTQEECLPWTNCSAFQQEVRRGTNSTDTTCSSQV, Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | TR2, HveA, CD270, Herpesvirus entry mediator A, Herpes virus entry mediator A, Tumor necrosis factor receptor-like 2, Tumor necrosis factor receptor superfamily member 14 |
Supplier: | United States Biological |
Supplier-Nr: | 516822 |
Properties
Conjugate: | No |
Host: | Mammalian cells |
Species reactivity: | mouse |
MW: | 45.6 kD |
Purity: | >=95% (SDS-PAGE) |
Format: | Lyophilized |
Database Information
KEGG ID : | K05152 | Matching products |
UniProt ID : | Q80WM9 | Matching products |
Gene ID | GeneID 230979 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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