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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-32-6572-2 | 2 µg | - | - |
3 - 11 business days* |
438.00€
|
||
ABE-32-6572-10 | 10 µg | - | - |
3 - 11 business days* |
554.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Source: Sf9, Baculovirus cells.Sterile Filtered colorless solution.Human TNFRSF10A is a type 1... more
Product information "TNFRSF10A Human"
Source: Sf9, Baculovirus cells.Sterile Filtered colorless solution.Human TNFRSF10A is a type 1 transmembrane protein in the TNF R superfamily. TNFRSF10A is not expressed in rodents. The trimeric ligand Trail binds TNFRSF10A and induces apoptosis, and recombinant, soluble forms of the receptor inhibit Trail-induced apoptosis. TNFRSF10A is expressed generally in damaged, infected, and malignant cells. TNFRSF10A functions in immune surveillance, inducing apoptosis in cancer cells but not normal cells.TNFRSF10A produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 224 amino acids (24-239a.a.) and having a molecular mass of 23.9kDa. (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). TNFRSF10A is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques. Protein function: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF- kappa-B (PubMed:9430227). [The UniProt Consortium]
Supplier: | Abeomics |
Supplier-Nr: | 32-6572 |
Properties
Conjugate: | No |
Host: | Insect cells |
Species reactivity: | human |
Database Information
KEGG ID : | K04722 | Matching products |
UniProt ID : | O00220 | Matching products |
Gene ID | GeneID 8797 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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