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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay37098-20 | 20 µg | - | - |
6 - 10 business days* |
250.00€
|
||
Cay37098-100 | 100 µg | - | - |
6 - 10 business days* |
625.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
TIM-4 is a type I transmembrane protein and member of the T cell immunoglobulin and mucin... more
Product information "TIM-4 Extracellular Domain (human, recombinant) - Biotinylated"
TIM-4 is a type I transmembrane protein and member of the T cell immunoglobulin and mucin domain-containing (TIM) family of immunoregulatory proteins. It is composed of an N-terminal immunoglobulin variable (IgV) domain that binds to phosphatidylserine, as well as a mucin stalk, which contains O- and N-linked glycosylation sites, a transmembrane domain, and a C-terminal cytoplasmic tail, which lacks a tyrosine phosphorylation site, unlike TIM-1 and TIM-3. TIM-4 is expressed in antigen-presenting cells (APCs) such as dendritic cells and macrophages and binds to TIM-1 on activated T cells. It is mainly involved in phagocytosis of apoptotic cells via recognition of phosphatidylserine, but also plays a role in T cell proliferation and survival, viral entry, and antitumor immunity. TIM-4 targeting antibodies prevent HIV-1 entry into host cells in vitro and enhance the efficacy of anticancer vaccines in a murine melanoma model. SNPs in TIMD4 are associated with increased susceptibility of asthma in children. Cayman's TIM-4 Extracellular Domain (human, recombinant) - Biotinylated protein consists of 302 amino acids, has a calculated molecular weight of 32.7 kDa, and a predicted N-terminus of Glu25 after signal peptide cleavage. By SDS-PAGE, the apparent molecular mass of the protein is approximately 60 kDa due to glycosylation.Synonyms: T Cell Immunoglobulin and Mucin Domain-containing Protein 4, T Cell Immunoglobulin Mucin Receptor 4, T Cell Membrane Protein 4, TIMD-4. Purity: >90% as determined by SDS-PAGE. Endotoxin Testing: <1.0 EU/µg determined by the LAL endotoxin assay. Source: Recombinant human C-terminal His-tagged TIM-4 extracellular domain expressed in HEK293 cells. Amino Acids: 25-315. MW: 32.7 kDa. Formulation: (Request formulation change), Lyophilized from sterile PBS, pH 7.4. UniProt Accession #: Q96H15.
Keywords: | TIM4, TIMD4, TIM-4, TIM-4, TIMD-4, TIMD-4, T-cell membrane protein 4, T-cell membrane protein 4, T-cell immunoglobulin mucin receptor 4, T-cell immunoglobulin mucin receptor 4, T-cell immunoglobulin and mucin domain-containing protein 4, T-cell immunoglob |
Supplier: | Cayman Chemical |
Supplier-Nr: | 37098 |
Properties
Conjugate: | Biotin |
Host: | Human cells |
Species reactivity: | human |
MW: | 32.7 kD |
Purity: | >90% as determined by SDS-PAGE |
Format: | Lyophilized |
Database Information
UniProt ID : | Q96H15 | Matching products |
Gene ID | GeneID 91937 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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