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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
009-001-T64S | 20 µg | - | - |
6 - 10 business days* |
272.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Recombinant full length human STUB1 (CHIP) was expressed in E. coli cells using an N-Terminal his... more
Product information "STUB1 (CHIP) protein-HIS Epitope"
Recombinant full length human STUB1 (CHIP) was expressed in E. coli cells using an N-Terminal his epitope. The purity was determined to be >95% by densitometry. Protein function: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). [The UniProt Consortium]
Keywords: | Antigen NY-CO-7, CLL-associated antigen KW-8, E3 ubiquitin-protein ligase CHIP, Carboxy terminus of Hsp70-interacting protein, STIP1 homology and U box-containing protein 1 |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 009-001-T64S |
Properties
Application: | WB |
Conjugate: | No |
Host: | Human |
Database Information
KEGG ID : | K09561 | Matching products |
UniProt ID : | Q9UNE7 | Matching products |
Gene ID | GeneID 10273 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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