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![ST2 Protein (isoform a, His Tag) (recombinant human)](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH030755.100 | 100 µg | - |
7 - 16 business days* |
869.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Activity: Measured by its binding ability in a functional ELISA.2. Immobilized recombinant human... more
Product information "ST2 Protein (isoform a, His Tag) (recombinant human)"
Activity: Measured by its binding ability in a functional ELISA.2. Immobilized recombinant human IL33 at 10 µg/mL (100 µl/well) can bind biotinylated human IL1RL1 (isoform A) with a linear range of 0.032-8 µg/ml. Protein Construction: A DNA sequence encoding the human IL1RL1 isoform A (NP_057316.3) (Met 1-Ser 328) was expressed, fused with a polyhistidine tag at the C-terminus. Sequence: Met 1-Ser 328. Fusion tag: C-His Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method. Protein function: IL-1 receptor-like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines. Protein function: Receptor for interleukin-33 (IL-33), signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. [The UniProt Consortium]
Keywords: | DER4, IL1RL1, Protein ST2, Interleukin-1 receptor-like 1, Recombinant Human ST2 Protein (isoform a, His Tag) |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH030755 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 36.3 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K05171 | Matching products |
UniProt ID : | Q01638 | Matching products |
Gene ID | GeneID 9173 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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