sRANKL Mouse (158-316), Active

Source: Escherichia Coli.Sterile Filtered colorless solution.Soluble RANK Ligand or type II membrane protein, is part of the TNF proteins family. RANKL has been found to have an effect on the immune system and regulates bone regeneration and remodeling. This protein regulates cell apoptosis, bunds to OPG protein (osteoprotegerin), cell proliferation regulator and acts as a ligand for RANK receptor. The protein is found to be expressed in various tissues such as thymus, colon, liver, skeletal muscle, osteoblast etc.sRANKL Mouse produced in E.Coli is a single, non-glycosylated polypeptide chain containing 160 amino acids (158-316a.a) and having a molecular mass of 17.9 kDa.sRANKL is purified by proprietary chromatographic techniques. Protein function: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts (PubMed:24039232, PubMed:18586671). During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (PubMed:23395171, PubMed:26644563). [The UniProt Consortium]