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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10206-25 | 25 µg | - |
6 - 10 business days* |
566.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Secretory phospholipase A2 (sPLA2) (Type IIA) is a calcium-dependent PLA2 superfamily member that... more
Product information "sPLA2 (human, recombinant Type IIA)"
Secretory phospholipase A2 (sPLA2) (Type IIA) is a calcium-dependent PLA2 superfamily member that is encoded by PLA2G2A in humans. It is composed of a highly-conserved calcium-binding loop, a catalytic domain, sPLA2 Type I- and II-specific disulfides that provide stability, and a C-terminal extension but lacks the N-terminal signal peptide found in sPLA2 (Type IB) and sPLA2 (Type X). sPLA2 (Type IIA) is expressed in platelets, synovial fluid, vascular smooth muscle cells, adipose tissue, the liver, and the gut. sPLA2 (Type IIA) functions in a cell- and tissue type-specific manner, preferentially hydrolyzing bacterial membrane phosphatidylglycerol (PG) and phosphatidylethanolamine (PE) as a mechanism of host defense. sPLA2 (Type IIA) is upregulated at sites of acute and chronic inflammation where it generates lysophosphatidic acid and arachidonic acid, which is further metabolized to inflammatory lipid mediators and a variety of eicosanoid autocrine and paracrine signaling molecules. Plasma levels of sPLA2 (Type IIA) are associated with the presence of sepsis and are increased in patients with rheumatoid arthritis, acute coronary syndrome, asthma, or inflammatory bowel disease (IBD). Cayman's sPLA2 (human, recombinant Type IIA) protein contains an asparagine to alanine substitution at position 1 to ensure proper removal of the N-terminal methionine during protein expression. Cayman's sPLA2 (human, recombinant Type IIA) can be used for enzyme activity assays. The specific activity of Cayman's sPLA2 (human, recombinant Type IIA) was established using Cayman's sPLA2 Assay Kit (Cay-765001) with 1.48 mM 1,2-bis(heptanoylthio) glycerophosphocholine (Cay-62235) as the substrate.Synonyms: GIIC sPLA2, Group IIA phospholipase A2, Non-Pancreatic Secretory Phospholipase A2, Phosphatidylcholine 2-Acylhydrolase 2A, Phospholipase A2, Membrane Associated, PLA2G2A, Secretory Phospholipase A2 (Group IIA), sPLA2-IIA. Purity: >85% estimated by SDS-PAGE. Source: Active recombinant human sPLA2 (Type IIA) expressed in E. coli. Amino Acids: 1-124, variant N1A. MW: 13.9 kDa. Formulation: (Request formulation change), 50 mM Tris-HCl, pH 7.6, with 100 mM sodium chloride and 10 mM calcium chloride. UniProt Accession #: P14555.
Keywords: | PLA2B, PLA2G2A, NPS-PLA2, NPS-PLA2, GIIC sPLA2, GIIC sPLA2, Group IIA phospholipase A2, Group IIA phospholipase A2, Phospholipase A2, membrane associated, Phospholipase A2, membrane associated, Phosphatidylcholine 2-acylhydrolase 2A, Phosphatidylcholine 2 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10206 |
Properties
Application: | Enzyme assays |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
Purity: | >85% estimated by SDS-PAGE |
Format: | Solution |
Database Information
KEGG ID : | K01047 | Matching products |
UniProt ID : | P14555 | Matching products |
Gene ID | GeneID 5320 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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