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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH030993.100 | 100 µg | - |
7 - 16 business days* |
869.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Activity: Measured by its binding ability in a functional ELISA.Immobilized human SIRPG-His at 10... more
Product information "SIRP gamma Protein (His Tag) (recombinant human)"
Activity: Measured by its binding ability in a functional ELISA.Immobilized human SIRPG-His at 10 µg/ml (100 µl/well) can bind human CD47-Fc , The EC50 of human CD47-Fc is 0.58-1.34 µg/ml. Protein Construction: A DNA sequence encoding the human SIRPG (NP_061026.2) extracellular domain (Met 1-Ser 364) was expressed, with a polyhistidine tag at the C-terminus. Sequence: Met 1-Ser 364. Fusion tag: C-His Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method. Protein function: Signal-regulatory protein gamma (SIRPG/SIRP gamma) also known as CD172 antigen-like family member B, CD172g, and CD172g antigen, is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. SIRPG/SIRP gamma/CD172g is probable immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG can mediate cell-cell adhesion. SIRPG/SIRP gamma is engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG/SIRP gamma/CD172g is detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. This cytokine is mainly present in the Protein function: Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T- cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. [The UniProt Consortium]
Keywords: | SIRPG, CD172g, SIRPB2, SIRP-b2, SIRP-gamma, SIRP-beta-2, Signal-regulatory protein gamma, Signal-regulatory protein beta-2, CD172 antigen-like family member B, Recombinant Human SIRP gamma Protein (His Tag) |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH030993 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 34.7 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K06551 | Matching products |
UniProt ID : | Q9P1W8 | Matching products |
Gene ID | GeneID 55423 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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