Shc, Recombinant, Human, aa1-474, His-tag (SHC1, Src homology and collagen, Src homology 2, FLJ26504

Shc, Recombinant, Human, aa1-474, His-tag (SHC1, Src homology and collagen, Src homology 2, FLJ26504
Item number Size Datasheet Manual SDS Delivery time Quantity Price
S1010-91G.100 100 µg - -

4 - 22 business days

451.00€
 
Signaling adapter that couples activated growth factor receptors to signaling pathways.... more
Product information "Shc, Recombinant, Human, aa1-474, His-tag (SHC1, Src homology and collagen, Src homology 2, FLJ26504"
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. [The UniProt Consortium]
Keywords: SHC-transforming protein 3, SHC-transforming protein 1, SHC-transforming protein A, Src homology 2 domain-containing-transforming protein C1
Supplier: United States Biological
Supplier-Nr: S1010-91G

Properties

MW: 53,8 kD
Format: Highly Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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