SF3B3 protein (GST tag), recombinant human

Activity: Testing in progress Protein Construction: A DNA sequence encoding the Human SF3B3 protein (Q15393-3) (Glu 250-Phe 399) was expressed with a GST tag. Sequence: Glu 250-Phe 399. Fusion tag: N-GST Endotoxin: Please contact us for more information. Apparent Molecular Mass: 42 kDa. Protein function: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it ma Protein function: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). [The UniProt Consortium]