Sas-6 protein (His tag), recombinant human

Activity: Testing in progress Protein Construction: A DNA sequence encoding the Human Sas-6 protein (Q6UVJ0) (Ser 201-Glu 420) was expressed with a N-His&C-His tag. Sequence: Ser 201-Glu 420. Fusion tag: N-His & C-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 32 kDa. Protein function: SASS6 (Spindle assembly abnormal protein 6 homolog) is required for centrosome duplication. It functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle. Overexpression results in excess foci bearing centriolar ma Protein function: Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124). [The UniProt Consortium]