SARS-CoV-2 (2019-nCoV) Papain-Like Protease Protein , recombinant

COVID-19 Research

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
E-PKSR030472.10	10 µg		-	-	7 - 16 business days*		240.00€
E-PKSR030472.50	50 µg		-	-	7 - 16 business days*		633.00€

You can also order using info@biomol.com or FAX at 0049-40-85326022
Bigger quantity required? Request Bulk

GenBank: QHD43415.1. Nsp3 is responsible for the cleavages located at the N-terminus of the... more

Close menu

Product information "SARS-CoV-2 (2019-nCoV) Papain-Like Protease Protein , recombinant"

GenBank: QHD43415.1. Nsp3 is responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling. [The Uniprot Consortium]

Keywords:	Non-structural protein 3, nsp3, PL2-PROPapain-like proteinase, PL-PRO, SARS coronavirus main proteinase
Supplier:	Elabscience
Supplier-Nr:	PKSR030472