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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay31844-100 | 100 µg | - | - |
6 - 10 business days* |
439.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
S100 calcium-binding protein A1 (S100A1) is a calcium-binding protein that exists as a homodimer,... more
Product information "S100A1 (human, recombinant)"
S100 calcium-binding protein A1 (S100A1) is a calcium-binding protein that exists as a homodimer, with each subunit containing two EF-hand calcium-binding domains connected by a hinge region and a C-terminal extension. It is expressed primarily in ventricular cardiomyocytes but also in skeletal muscle and vascular endothelial cells. In cardiomyocytes it is localized to the sarcoplasmic reticulum, mitochondria, and myofilaments where it regulates calcium homeostasis, contractile machinery, and cellular energy metabolism. S100A1 is localized to the cytoplasm with perinuclear enrichment in micro- and macrovascular endothelial cells and regulates responses to adrenergic receptor activation, vessel relaxation, and angiogenesis. Overexpression of S100A1 is protective against the development of heart failure in post-ischemic isolated mouse cardiomyocytes and reduces mortality in a mouse model of myocardial infarction. S100A1 knockdown impairs post-ischemic angiogenesis and neovascularization in mice. S100A1 levels are inversely correlated with disease severity in patients with heart failure. Cayman's S100A1 (human, recombinant) protein can be used for binding assay applications. This protein is a disulfide-linked homodimer. The reduced monomer, composed of S100A1 (amino acids 2-94) fused to human IgG1 Fc at its C-terminus, consists of 330 amino acids and has a calculated molecular weight of 37.1 kDa. As a result of glycosylation, the monomer migrates at 40 kDa by SDS-PAGE under reducing conditions.Synonyms: S100alpha, S100 Calcium-binding Protein A1, S100 Protein alpha Chain, S100 Protein Subunit alpha. Purity: >95% estimated by SDS-PAGE. Endotoxin Testing: <1.0 EU/µg, determined by the LAL endotoxin assay. Source: Active recombinant C-terminal human IgG1 Fc-tagged S100A1 expressed in HEK293 cells. Amino Acids: 2-94. MW: 37.1 kDa. Formulation: (Request formulation change), Lyophilized from sterile 50 mM Tris, pH 7.5, with 100 mM glycine and 10 mM sodium chloride. UniProt Accession #: P23297.
Keywords: | S100A, S100A1, Protein S100-A1, Protein S100-A1, S-100 protein alpha chain, S-100 protein alpha chain, S-100 protein subunit alpha, S-100 protein subunit alpha, S100 calcium-binding protein A1, S100 calcium-binding protein A1 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 31844 |
Properties
Conjugate: | No |
Purity: | >95% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K23758 | Matching products |
UniProt ID : | P23297 | Matching products |
Gene ID | GeneID 6271 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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