Retinol-binding protein 1/RBP1 Protein (recombinant human)

Protein Construction: Recombinant Human Retinol-binding Protein 1 is produced by our E.coli expression system and the target gene encoding Pro2-Gln135 is expressed. Sequence: Pro2-Gln135. Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 14 kDa. Protein function: Retinol-binding proteins (RBP) are a family of proteins with diverse functions. They are carrier proteins that bind retinol. Retinol and retinoic acid play crucial roles in the modulation of gene expression and overall development of an embryo. However, deficit or excess of either one of these substances can cause early embryo mortality or developmental malformations. Regulation of transport and metabolism of retinol necessary for a successful pregnancy is accomplished via RBP. Retinol binding proteins have been identified within the uterus, embryo, and extraembryonic tissue of the bovine, ovine, and porcine, clearly indicating that RBP plays a role in proper retinol exposure to the embryo and successful transport at the maternal-fetal interface. Protein function: Cytoplasmic retinol-binding protein (PubMed:22665496, PubMed:26900151, PubMed:28057518). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (PubMed:15632377, PubMed:22665496). [The UniProt Consortium]