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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-32-9361-50 | 50 µg | - | - |
3 - 11 business days* |
634.00€
|
||
ABE-32-9361-500 | 500 µg | - | - |
3 - 11 business days* |
1,888.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Source : Human Cells,Kin of irregular chiasm-like protein 1(Kirrel1), also known as Nephrin-like... more
Product information "Recombinant Mouse Kirrel1/Neph1(C-6His)"
Source : Human Cells,Kin of irregular chiasm-like protein 1(Kirrel1), also known as Nephrin-like protein 1(Neph1), belongs to the immunoglobulin superfamily. Kirrel1 plays a significant role in the normal development and function of the glomerular permeability. It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. The knockout of this gene could result in perinatal lethality accompanied by proteinuria, and effacement of glomerular podocytes. Kirrel1 is abundantly expressed in kidney and specifically expressed in podocytes of kidney glomeruli. Its' subunit interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus) and interacts with NPHS1/nephrin (via the Ig-like domains). This interaction is dependent on KIRREL glycosylation. Kirrel1 also interacts when tyrosine-phosphorylated with GRB2. Protein function: Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:11416156). Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. [The UniProt Consortium]
Supplier: | Abeomics |
Supplier-Nr: | 32-9361 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | mouse |
Database Information
UniProt ID : | Q80W68 | Matching products |
Gene ID | GeneID 170643 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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