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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-RPES4588.50 | 50 µg | - | - | - |
9 - 20 business days* |
1,272.00€
|
|
G-RPES4588.100 | 100 µg | - | - |
9 - 20 business days* |
1,272.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Receptor for Wnt proteins (PubMed:11092808, PubMed:18230341). Can activate... more
Product information "Recombinant Mouse Frizzled-5/FZD5 Protein (Fc Tag) (RPES4588)"
Protein function: Receptor for Wnt proteins (PubMed:11092808, PubMed:18230341). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro), the in vivo situation may be different since not all of these are known to be coexpressed (PubMed:11092808). In neurons, activation of WNT7A promotes formation of synapses. Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:18230341). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:18230341). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (PubMed:11092808). [The UniProt Consortium]
Keywords: | Fzd5, Fz-5, mFz5, Frizzled-5 |
Supplier: | Assay Genie |
Supplier-Nr: | RPES4588 |
Properties
Conjugate: | No |
Species reactivity: | mouse |
Format: | Highly Purified |
Database Information
KEGG ID : | K02375 | Matching products |
UniProt ID : | Q9EQD0 | Matching products |
Gene ID | GeneID 14367 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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