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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-RPES3993.50 | 50 µg | - | - | - |
9 - 20 business days* |
1,015.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Mouse FGFR4/CD334 Recombinant Protein (RPES3993) is a highly pure recombinant protein developed... more
Product information "Recombinant Mouse FGFR4/CD334 Protein (His & Fc Tag)(Active) (RPES3993)"
Mouse FGFR4/CD334 Recombinant Protein (RPES3993) is a highly pure recombinant protein developed by Assay Genie for use in a range of applications Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation, MMP14 promotes internalization and degradation of FGFR4. Plays a role in postnatal lung development. May be involved in the development of skeletal muscle cell lineages. [The UniProt Consortium]
Keywords: | Fgfr4, CD334, FGFR-4, Fgfr-4, EC=2.7.10.1, Fibroblast growth factor receptor 4, Protein-tyrosine kinase receptor MPK-11 |
Supplier: | Assay Genie |
Supplier-Nr: | RPES3993 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | mouse |
Format: | Highly Purified |
Database Information
KEGG ID : | K05095 | Matching products |
UniProt ID : | Q03142 | Matching products |
Gene ID | GeneID 14186 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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