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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-32-7027-10 | 10 µg | - | - |
3 - 11 business days* |
381.00€
|
||
ABE-32-7027-50 | 50 µg | - | - |
3 - 11 business days* |
469.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Source: E.coli. MW :17.26kD. Recombinant Human Interleukin-1 Receptor Antagonist Protein is... more
Product information "Recombinant Human IL-1 Receptor Antagonist Protein/IL-1RA/IL-1F3"
Source: E.coli. MW :17.26kD. Recombinant Human Interleukin-1 Receptor Antagonist Protein is produced by our E.coli expression system and the target gene encoding Arg26-Glu177 is expressed. Interleukin-1 Receptor Antagonist (IL-1RN) is a member of the IL-1 family. Endogenous IL-1RN is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL-1RN. The regulated expression of IL-1RN in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts, IL-1, TNF-alpha, or PDGF markedly enhances the synthesis of IL-1RN. Protein function: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2, however, the physiological relevance of the latter association is unsure. [The UniProt Consortium]
Supplier: | Abeomics |
Supplier-Nr: | 32-7027 |
Properties
Conjugate: | No |
Database Information
KEGG ID : | K05481 | Matching products |
UniProt ID : | P18510 | Matching products |
Gene ID | GeneID 3557 | Matching products |
Handling & Safety
Storage: | +20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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