Recombinant Human Fas/CD95/TNFRSF6 Protein (His Tag) (RPES4290)

Human Fas/CD95/TNFRSF6 Recombinant Protein (RPES4290) is a highly pure recombinant protein developed by Assay Genie for use in a range of applications Protein function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). [The UniProt Consortium]