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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PDEH100342.20 | 20 µg | - |
7 - 16 business days* |
81.00€
|
|||
E-PDEH100342.100 | 100 µg | - |
7 - 16 business days* |
141.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Activity: Testing in progress Protein Construction: A DNA sequence encoding the Human RAD1... more
Product information "RAD1 protein (His tag), recombinant human"
Activity: Testing in progress Protein Construction: A DNA sequence encoding the Human RAD1 protein (O60671) (Met 1-Ser 282) was expressed with a N-His&C-His tag. Sequence: Met 1-Ser 282. Fusion tag: N-His & C-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 35 kDa. Protein function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platfo Protein function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity (PubMed:9660799). [The UniProt Consortium]
Keywords: | RAD1, REC1, hRAD1, Cell cycle checkpoint protein RAD1, DNA repair exonuclease rad1 homolog, Rad1-like DNA damage checkpoint protein, Recombinant Human RAD1 protein (His tag) |
Supplier: | Elabscience |
Supplier-Nr: | E-PDEH100342 |
Properties
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 30.91 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K02830 | Matching products |
UniProt ID : | O60671 | Matching products |
Gene ID | GeneID 5810 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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