PTPMT1, Recombinant, Human, aa2-201, GST-tag (Protein Tyrosine Phosphatase Mitochondrial 1, PTEN-Lik

Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity), Source: Recombinant protein corresponding to aa2-201 from human PTPMT1, fused to GST-tag at N-terminal, expressed in Sf9 insect cells. Molecular Weight: ~49.3kD, Applications: Suitable for use as an immunogen, in binding assays or as an antigen in autoimmuneassays. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.