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Product information "PtdIns-(4,5)-P2 Binding Protein (GST-tagged)"
Pleckstrin homology (PH) domains all contain a seven-standard b-sandwich that allows binding to various species of phosphatidylinositol (PtdIns) phosphates. Most PH domains bind to PtdIns phosphates with weak affinity and low specificity. However, a small subclass binds specifically and with high-affinity for certain PtdIns phosphates. PtdIns-(4,5)-P2 Binding Protein (GST-tagged) contains a highly specific PH domain that recognizes and binds PtdIns-(4,5)-P2 (see Figure 1). PtdIns phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.{4096, 8344} PtdIns-(4,5)-P2 can be phosphorylated by phosphoinositide (PI)-3-kinase to make PtdIns-(3,4,5)-P3 which initiates an intricate signaling cascade that has been implicated in cancer PtdIns-(4,5)-P2 binding protein can be used in in vitro assays for the detection of PtdIns-(4,5)-P2 in PI3-kinase and PTEN phosphatase assays.Synonyms: Phosphatidylinositol-4,5-diphosphate, PI(4,5)-P2, PI(4,5)P2 Binding Protein, PIP2, PIP2[4',5'] Binding Protein, PLC-delta1-PH Domain. Purity: >90%. Source: Recombinant GST-tagged protein purified from E. coli. MW: ~45.2 kDa. Formulation: (Request formulation change), A solution in PBS, pH 7.4, containing 20% glycerol.
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