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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-40B-0190-C050 | 50 µg | - |
3 - 9 business days* |
407.00€
|
|||
AG-40B-0190-C500 | 500 µg | - |
3 - 9 business days* |
3,190.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent... more
Product information "PSGL-1 (human):Fc (human) (rec.)"
Protein function: A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. [The UniProt Consortium] P-selectin glycoprotein ligand-1 (PSGL-1) is a 120kda transmembrane homodimer protein that is primarily expressed on lymphoid and myeloid cells, including platelets. PSGL-1 was first identified to regulate the rolling/tethering of neutrophils on activated endothelium through P-selectin binding. PSGL-1 binds P-, E- and L- selectin through the N-terminus of the extracellular domain upon special glycosylation (sialyl Lewis x). PSGL-1 functions in regulating the migration of macrophages/monocytes, plasma B cells, dendritic cells and T cells by selectin engagement. PSGL-1 also regulates localization of macrophages, dendritic cells and B cells in the lamina propria at steady state. Although PSGL-1 is expressed on resting T cells, selectin binding capacity is only acquired during the proliferation/differentiation of effector T cells. In addition to its migratory properties, the adhesion protein PSGL-1 also functions in a selectin-independent manner as a negative regulator of T cell responses in contexts of chronic viral infection, cancer and some autoimmune diseases. For this immune checkpoint function, it has recently been reported that PSGL-1 binds the negative immune checkpoint regulator VISTA (V-domain immunoglobulin suppressor of T cell activation). PSGL-1 expressed on leukocytes binds to multimeric VISTA at acidic pH, but not at the physiological pH 7. This acidic influence of the binding is due to multiple histidine residues protonation located in the VISTA extracellular domain. VISTA - PSGL-1 interaction shows that immune response can be regulated by acidic environments found in tumors. Identification of PSGL-1 - VISTA signaling pathways in T cells could lead to new therapeutic targets that increase immune function, such as in chronic viral infections or in cancer, or attenuate immune function such as in autoimmunity.
Keywords: | CD162, SELPLG, PSGL-1, Selectin P ligand, P-selectin glycoprotein ligand 1 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-40B-0190 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 95-100 kD |
Purity: | >=95% (SDS-PAGE) |
Format: | Lyophilized |
Database Information
KEGG ID : | K06544 | Matching products |
UniProt ID : | Q14242 | Matching products |
Gene ID | GeneID 6404 | Matching products |
Handling & Safety
Storage: | -20°C (avoid repeat freezing and thawing cycles) |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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