POSTN Protein (His Tag), recombinant human

Activity: Testing in progress Protein Construction: A DNA sequence encoding the Human POSTN (Q15063-1) (Ala21-Leu365) was expressed with a polyhistidine tag at the N-terminus. Sequence: Ala21-Leu365. Fusion tag: N-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 40.3 kDa. Protein function: Periostin (POSTN,PN),originally named as osteoblast-specific factor 2 (OSF-2),is a 90-kDa secreted protein which is now classified as a matricellular protein. It is present in a wide variety of normal adult tissues and fetal tissues,and has a role in bone,tooth and heart development and function. Studies show that periostin is overexpressed in a broad range of human cancer types,includidng lung,ovary,breast and colon cancers. Recent evidence reveals that periostin is expressed by fibroblasts in the normal tissue and in the stroma of the primary tumour,and it is required to allow cancer stem cell maintenance. Protein function: Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX. [The UniProt Consortium]