PAK6 protein (His tag), recombinant human

Activity: Testing in progress Protein Construction: A DNA sequence encoding the Human PAK6 protein (Q9NQU5) (Met 1-Cys 681) was expressed with a N-His&C-His tag. Sequence: Met 1-Cys 681. Fusion tag: N-His & C-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 80 kDa. Protein function: As downstream targets of the Rho GTPases, the p21-activated kinase (PAK) family of serine/threonine kinases regulates the organization of the actin cytoskeleton in mammalian cells. The PAK family is structurally categorized in two groups, each with three Protein function: Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR- mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. [The UniProt Consortium]