OGG1, Human

Sequence: MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ SPAHWSGVLA DQVWTLTQTE EQLHCTVYRG DELEAVRKYF QLDVTLAQLY HHWGSVDSHF QEVAQKFQGV RLLRQDPIEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG SLQALAGPEV EAHLRKLGLG YRARYVSASA RAILEEQGGL AWLQQLRESS YEEAHKALCI LPGVGTKVAD CICLMALDKP QAVPVDVHMW IAQRDYSWHP TTSQAKGPSP QTNKELGNFF RSLWGPYAGW AQAVLFSADL RQCRHAQEPP AKRRKGSKGP with polyhistidine tag at the C-terminus Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. [The UniProt Consortium]