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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay24731-10 | 10 µg | - |
6 - 10 business days* |
2,042.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Melatonin receptor type 1A (MT1) (human recombinant) contains amino acids corresponding to the... more
Product information "Melatonin Receptor Type 1A (human recombinant)"
Melatonin receptor type 1A (MT1) (human recombinant) contains amino acids corresponding to the full length, wild-type human MT1 receptor, as well as N-terminal histidine and streptavidin tags with a TEV protease cleavage site. The MT1 receptor is encoded by the MTNR1A gene and is a G protein-coupled receptor expressed on post-synaptic terminals in the suprachiasmic nucleus (SCN) and hypothalamus. It is activated by melatonin and signals through Gi and Gq proteins. Based on MT1 and MT2 receptor knockout mouse studies, the MT1 receptor is involved in decreasing neuronal firing in the SCN and inhibits prolactin secretion in the pituitary gland. MT1 receptor activation inhibits proliferation of hormone-refractory 22Rv1 prostate cancer cells in vitro. Polymorphisms in the MTNR1A gene are associated with a higher risk of oral cancer and hepatocellular carcinoma and of developing distant metastasesSynonyms: MT1. Purity: >90% estimated by SDS-PAGE. Source: Human melatonin receptor type 1A (MT1) purified from a baculovirus overexpression system in Sf9 cells. Amino Acids: Full length, wild-type sequence. MW: 44.8 kDa. Formulation: (Request formulation change), 25mM disodium phosphate, pH 8.0, 150 mM sodium chloride, 0.86%/0.18% sarkosyl/CHS. UniProt Accession #: P48039.
Keywords: | MTNR1A, Mel-1A-R, Mel-1A-R, Mel1a receptor, Mel1a receptor, Melatonin receptor type 1A, Melatonin receptor type 1A |
Supplier: | Cayman Chemical |
Supplier-Nr: | 24731 |
Properties
Conjugate: | No |
Purity: | >90% estimated by SDS-PAGE |
Format: | Solution |
Database Information
KEGG ID : | K04285 | Matching products |
UniProt ID : | P48039 | Matching products |
Gene ID | GeneID 4543 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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