MCEE Protein (His Tag), recombinant human

Activity: Testing in progress Protein Construction: Recombinant Human Methylmalonyl-CoA epimerase is produced by our Mammalian expression system and the target gene encoding Gln37-Ala176 is expressed with a 6His tag at the C-terminus. Sequence: Gln37-Ala176. Fusion tag: C-His Endotoxin: <1.0 EU per µg of the protein as determined by the LAL method. Apparent Molecular Mass: 18-20 kDa. Protein function: Methylmalonyl-CoA epimerase, mitochondrial(MCEE)is an enzyme which belongs to the glyoxalase I family. It converts (S)-methylmalonyl-CoA to the (R) form, catalyses the following chemical reaction: (R)-methylmalonyl-CoA (S)-methylmalonyl-CoA. It plays an important role in the catabolism of fatty acids with odd-length carbon chains. This protein deficiency is an autosomal recessive inborn error of AA metabolism, involving valine, threonine, isoleucine and methionine. This organic aciduria can appear in the neonatal period with life-threatening metabolic acidosis, hyperammonemia, feeding difficulties, pancytopenia and coma. Protein function: Methylmalonyl-CoA epimerase involved in propionyl-CoA metabolism. [The UniProt Consortium]