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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH032706.10 | 10 µg | - |
7 - 16 business days* |
265.00€
|
|||
E-PKSH032706.50 | 50 µg | - |
7 - 16 business days* |
705.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein Construction: Recombinant Human LIM and cysteine-rich domains protein 1 is produced by... more
Product information "LIM and Cysteine-Rich Domains Protein 1/LMCD1/Dyxin Protein(N, C-6His) (recombinant human)"
Protein Construction: Recombinant Human LIM and cysteine-rich domains protein 1 is produced by our E.coli expression system and the target gene encoding Met1-Ser365 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus. Sequence: Met 1-Ser365. Fusion tag: N,C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 45 kDa. Protein function: LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. LMCD1 is expressed in many tissues with highest abundance in skeletal muscle. LMCD1 restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. It plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. Protein function: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. [The UniProt Consortium]
Keywords: | Dyxin, LMCD1, LIM and cysteine-rich domains protein 1, Recombinant Human LIM and Cysteine-Rich Domains Protein 1/LMCD1/Dyxin Protein(N, C-6His) |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH032706 |
Properties
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 44.0 kD |
Format: | Solution |
Database Information
KEGG ID : | K24417 | Matching products |
UniProt ID : | Q9NZU5 | Matching products |
Gene ID | GeneID 29995 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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